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27 The largest declines noted were in Quebec (from 30.3% in 1999 to 15.7% in 2017) and Prince Edward Island (PEI) (from 25.6% in 1999 to 11.8% in 2017) while British Columbia had the lowest overall reduction in smoking prevalence (from 20% in 1999 to 15.6% in 2017)

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[PMC free article] [PubMed] [Google Scholar] 35.Jeng JH, Hoh LJ, Lin BR, Hsieh CC, Chan CP, Chag MC

Isolation from Tobacco mosaic virus-infected tobacco of a solubilized template-specific RNA-dependent RNA polymerase containing a 126K/183K protein heterodimer

In fact, there is twice as much nicotine in smokeless tobacco as in an average cigarette