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5 If current tobacco use patterns persist, an estimated 5.6 million of todays youth under age 18 eventually will die prematurely from a smoking-related disease

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In this study we also adjusted for HHS, but compared to other SEP variables it was found to have little additional impact as a confounder of the active-smoking-mortality relationship

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Importantly, impaired vascular endothelial function is acknowledged as an early key event in the initiation and progression of smoking-induced atherosclerosis