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Cancer and the total deaths due to smoking have fallen sharply in men in high-income countries but will rise globally unless current smokers, most of whom live in low- and middle-income countries, stop smoking before or during middle age

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doi:10.1016/j.neubiorev.2016.11.013

Burley Tobacco Burley tobacco is a variety of tobacco grown in Kentucky, Tennessee, and other states in the Appalachian US