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Since the vagus nerve does not innervate the spleen but terminates in the celiac-mesenteric ganglia [42], these results were surprising

Nicotine is genotoxic and can play oncogenic and carcinogenic effects in the liver

Yet the actual components of cigarette smoke that interact with the intestinal mucosa, immune cells and microbiota leading to and/or influencing this disease state remain elusive

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Immunol Lett 224, 2829

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