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85 conducted a meta-analysis of 33 Cochrane Reviews and found that behavioral interventions for smoking cessation such as any form of counseling along with guaranteed financial incentives provided the most motivation to quit for six months or longer 85

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While a study found that IQOS was less cytotoxic than CS to human lung epithelial cell line (A549) (9095% estimated reduction in cytotoxicity), both products yielded reduced levels of glutathione (antioxidant) and increased carbonylation of proteins (markers of chronic lung diseases) 23

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21, ninth among companies classified as "mid-size"