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Semaglutide is a powerful weight loss tool, but patients with existing kidney disease need careful monitoring
Semaglutide showed the strongest connection to lowered risk

Novo Nordisk was close behind, also generating nearly $12 billion, driven by massive demand for Ozempic and Wegovy

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In mice lacking GLP-1R specifically in these endothelial cells, semaglutide still induced weight loss, but the beneficial effects on the liver were lost
