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5000 different chemical compounds, 7 with 44 of them confirmed to be genotoxic and cytotoxic, according to the Hoffmann list, including inorganic compounds, ethers, hydrocarbons, amines, phenols, alcohols, ketones, aldehydes, carboxylic acids, and amides

The earliest description of Khat in western literature was in 1697 by the French Barthlmyd'Herbelot de Molainville when he travelled to Yemen, he specifically said (translated) [It] is made with a seed which is unknown to us, which has been forbidden by the doctors of the law in the province of Yemen where it originated.because it is too strong, and affects the brain

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Additionally, cigars contain natural tobacco leaves that dont break down quickly