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As a sensitivity test, the one-step DerSimonian and Laird estimator provides a summary effect of -1.12 (-1.46 -0.78) which is not meaningfully different from the two-step result

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These features enable a more accurate representation of the lungs microenvironment, allowing for real-time study of cellular responses to cigarette smoke

They are particularly popular among first-time users and younger consumers who prefer hassle-free options that require no maintenance or refilling