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The significance of such findings lies in the potential for nicotine to directly affect the airway in the context of smoking or vaping, promoting AHR, and remodeling

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[DOI] [PubMed] [Google Scholar] 9.Schfer T, Nienhaus A, Vieluf D, Berger J, Ring J

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In Europe, it tends to appear as a gel or a cream, while in the U.S., patches and body sleeves are very frequently used, e.g.: Tiger Balm, or IcyHot patches or knee/elbow sleeves