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second, the knockdown of SESN2 leads to a reduction in the translocation of p62 to the mitochondria and decreases its phosphorylation level at critical sites (such as Ser403), which is necessary for the encapsulation of the mitochondria by autophagosomes

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Abrupt discontinuation of certain drugs particularly beta-blockers can carry its own risks, as outlined in the relevant Summary of Product Characteristics (SmPC) available via the MHRA/EMC