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R.VigneriR.et al (1992)

Consuming excessive amounts of coffee, such as more than four cups a day, can cause several side effects, such as: Insomnia: Caffeine can interfere with sleep quality, especially if consumed close to bedtime

This moderate reduction from standard variants creates a balanced experience that appeals to smokers who want restraint without feeling like they're smoking air

The throat hit simulates the feeling of smoking and depending on the level of nicotine within the e-liquid, it can be increased or decreased accordingly

So it could be that some are safer or more harmful than others

In fact, criminal organizations seem to be the only beneficiaries