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Funding This work was partially supported by National Institutes of Health NORC Center Grants P30DK072476, Pennington/Louisiana, P30DK040561, Harvard, and R01DK109008, Shape UP

Author Contributions: All authors worked with this patient and wrote and revised the manuscript

Therefore, a delivery system is needed to enable FAs to reach the distal part of the gastrointestinal (GI) tract, which is rich in L-cells

Proper placement and cannula patency were verified via 5-thio-D-glucose (210 g)-induced hyperglycemia, as previously described 84

These findings suggest that central FGF21 signaling is required for the full effect of liraglutide-induced weight loss, supporting our hypothesis that liraglutide-induced FGF21 signals to the central nervous system to facilitate the weight-lowering actions of liraglutide

Semaglutide GLP-1 injections were originally developed to treat individuals with type 2 diabetes