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High stress levels, family problems, alcohol use and depression are all associated with risk for relapse

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These data suggest that adding in a behavioral substitute, like a VLNC, might be another helpful tool to tackling tobacco addiction. The Options study was made possible by a $1.4 million three-year grant from the National Cancer Institute and Food and Drug Administration to the University of Wisconsin Center for Tobacco Research and Intervention

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Several case-control and cohort studies have shown that female smokers have a higher risk of lung cancer than male smokers with the same smoking quantity [44,45,46,47], whereas other cohort studies have shown a similar incidence of lung cancer with comparable smoking histories [48, 49]