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Furthermore, cigarette smoke exposure upregulated MMP-9 and inhibited adaptive remodeling in a rat model of volume overload, leading to eccentric hypertrophy and impaired ventricular function, indicating overlap in the mechanisms of nicotine- and cigarette-induced pathology (49)

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Exposure to tobacco smoke while in the womb and smoking in the teenage years have both been shown to cause long-term problems regarding brain development

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