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CR hi intrahepatic cholangiocarcinoma tumors were also enriched for purines compared with pyrimidines (Figure 7C), consistent with their downregulated CPS1 activity that reduced the supply of carbamoyl phosphate to de novo pyrimidine synthesis and enhanced aspartate availability for de novo purine synthesis
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[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Polyzos A, Schmid TE, Pia-Guzmn B, Quintanilla-Vega B, Marchetti F
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