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Additionally, it has been found that chronic nicotine use leads to nAChR receptor desensitization and inactivation during stages of withdrawal, which are reactivated upon overnight abstinence (106, 107)

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Food and Drug Administration instead will undertake research to support a new rule-making consistent with the Tobacco Control Act, the FDA said in a written statement, meaning the agency will have to create new warning labels to comply with the 2009 law