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Enteroendocrine cells (EEC) found scattered throughout the intestine comprise approximately only 1% of the epithelium but secrete more than 20 different peptide hormones, making them collectively one of the largest endocrine systems (14)

While he has long maintained a keen interest in AI, more recently Brian has made making data analysis a central focus, and is exploring tools ranging from NLP and clustering to predictive analytics

R., Aune D., et al., Body Mass Index and Survival in Women With Breast CancerSystematic Literature Review and MetaAnalysis of 82 FollowUp Studies, Annals of Oncology 25 (2014): 19011914

We and others previously demonstrated GDF8 and ActA are the two major ligands which mediate the muscle minimization actions of the ActRIIA/B receptors in non-obese mice and NHPs 22,28,30 , and we have further shown that dual blockade of GDF8 and ActA led to much larger increases in muscle mass than blocking either ligand individually, and that dual blockade matched the muscle growth actions of broader ActRIIA/B blockade 28 , similar to effects seen when using a dominant-negative type II receptor or pro-domains of GDF8 and activins 22,26,27

Key points for future research include the following