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adults who have smoked cigarettes in the past week say they smoke less than one pack of cigarettes, 25% smoke one pack and 6% smoke more than one pack

Moreover, the market is benefiting from the availability of a variety of products, from traditional to modernized versions of smokeless tobacco

In particular, cigarette smoke was found to induce alveolar macrophages and neutrophils to produce pro-inflammatory cytokines, reactive oxygen species, matrix metalloproteinases, and various chemokines 31

NIDA Research Monograph (17): 23088

Common side effects are insomnia, agitation, dry mouth, and headache

The mouth is especially susceptible to harmful effects of smoking