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Epigenetics is usually defined as heritable alterations in gene expression patterns that are not directly caused by modifications encoded in the nucleotide genome sequence but are caused by posttranslational modifications in DNA and histone proteins and by the regulation of non-coding RNAs (ncRNAs) [6]

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1989 Carcinogenesis 10 : 21492153 Witschi H

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Alternatively, p53 can activate autophagy or induce premature senescence of the cells to prevent their oncogenic transformation [14]

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Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305

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