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Moreover, the rapidly evolving nature of e-cigarette products and formulations means that some findings may not fully reflect current market trends or emerging devices

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low certainty).40 Pharmacotherapy and combined behavioural and pharmacotherapy interventions Our review showed that bupropion may result in little to no harm, although data were of very low certainty or could not be evaluated for certainty because not enough data were provided.22 An updated Cochrane review on bupropion41 suggested there may be a small increase in adverse events, which could constitute a small harm (Appendix 1 and Appendix 2)

More recently, American entrepreneurs have taken a leaf from the success of herbal cigarettes in Asia to market non-tobacco herbal smokes to trendy Millennials and nicotine-weary tobacco addicts

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