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Prostaglandin E2 (PGE 2) Prostaglandins enhance mucosal blood flow, mucosal secretion, and bicarbonate synthesis while decreasing stomach acid output

This is the feeling that the researchers are targeting, said Travis Denton, assistant professor of pharmaceutical sciences, lead author and a former tobacco chewer who has been working on solutions to nicotine dependence for 15 years

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CONCLUSION Mounting evidence demonstrates that nicotine addiction can induce offensive, defensive, and carcinogenic processes in the GI tract

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Previous risk assessment of tobacco (both financed and co-authored by the tobacco industry) have looked at various compounds but not included nicotine itself 22,23