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A 2007 review of public health studies found that non-smoking adult tobacco workers have similar levels of nicotine in their bodies as smokers in the general population, althoughindividual variation would be expected based upon the use of personal protective equipment, season and contact with tobacco, and abrasions on the skin, as well as other factors.[66] Working in excessive heat and engaging in heavy physical activity, which are typical for workers, including child workers, engaged in tobacco farming in the United States, also increase the risk of nicotine poisoning as the increase in surface blood flow to help reduce body temperature facilitates nicotine absorption.[67] Though public health research has most often looked at nicotine poisoning among adult workers handling mature tobacco leaves, nicotine is present in tobacco plants and leaves in any form

you're trying to harden that sugar and get it more baked into the leaf before you start the process of drying everything else down." Within the leaf, sap and Chlorophyll, for example, are not desirable for tobacco use, so they are drawn out through the curing process

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155 The FFDCA prohibits the adulteration and misbranding of tobacco products, as well as the introduction, receipt, and delivery of adulterated or misbranded tobacco products into interstate commerce