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Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures

Unlike NOX2, which primarily produces superoxide radicals, NOX4 produces H 2 O 2 which has known benefits in the cardiovascular system, such as endothelial cell growth and proliferation and regulation of endothelial barrier function [12]

Cigarettes and other combustible tobacco products are responsible for the overwhelming burden of death and disease from tobacco use in the United States, said Corinne Graffunder, Dr.PH., M.P.H., director of CDCs Office on Smoking and Health

A new study published in PLOS Medicine takes a closer look, examining how smoking intensity and cessation relate to a wide range of heart and health outcomes