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our results from animal models point to a metastasis-promoting effect of e-cig on breast carcinoma [28], the recent study also found that exposure to the main components of electronic cigarettes, PG/VG and nicotine, significantly promotes tumor invasion, metastasis, and immunosuppression, while also increasing immune checkpoint markers like CTLA4 and PD-1, although these effects could be mitigated through immune checkpoint blockade therapy

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