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Reported in the Journal Science , the study provides a direct link between the number of cigarettes smoked in a lifetime and the number of mutations in the tumour DNA

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The authors found evidence of ultrastructural abnormalities in cardiomyocytes, including shrunken nuclei with chromatin condensation and fragmentation (apoptosis), nuclear malformation with extensively convoluted nuclear membranes, myofibrillar derangement, thinning and destruction, intramyocardial lipid accumulation and mitophagy, which are associated with myocardial dysfunction

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