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Studies have also shown increase in M1/M2 macrophages and mast cells in people who smoke and patients with COPD [44,45,46]

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For example, the DPH administers the California Tobacco Control Programa Proposition 99 programthat funds activities to reduce illness and death from tobacco-related diseases with a budget of about $45 million in 2015-16

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6.2 Marlboros Shift Toward Smoke-Free Alternatives Philip Morris International (PMI), Marlboros parent company, continues to push toward a smoke-free future, investing in IQOS and other heat-not-burn devices