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Nicotine and other stimulants in vaping products can activate the bodys fight or flight response and reduce heart rate variability, which may lead to irregular heart rhythms (arrhythmias) and, in severe cases, sudden cardiac arrest

Carnes MU, Hoppin JA, Metwali N, Wyss AB, Hankinson JL, O'Connell EL, Richards M, Long S, Freeman LE, Sandler DP, Henneberger PK, Barker-Cummings C, Umbach DM, Thorne PS, London SJ

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After screening 2481 titles against the inclusion and exclusion criteria, followed by abstract screening and full-text retrieval, 113 studies were included in the final review