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Gallstones Research shows that the risk of developing gallstones increases in smokers

doi: 10.1016/S0140-6736(99)04030-1

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The menthol refills have been designed to taste as similar to a mentholated cigarette as possible

It dramatically diminishes the excitatory effects of nicotine on VTA dopamine neurons and on the glutamatergic and GABAergic synaptic inputs to these neurons