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Although the excessive use of certain performance-enhancing drug (PED) classes is associated with clear health risks, current evidence on PED-related cardiovascular (CV) risk is primarily derived from retrospective reports, small cohorts, or illicit use, leaving major gaps in mechanistic understanding and doseresponse relationships in performance enhancement, well-being, and rehabilitation purposes

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In late-stage type 2 diabetes mellitus (T2DM), impaired islet cell function leads to absolute insulin deficiency, thereby disrupting blood glucose homeostasis

2020;132:110831

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