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50 Such studies are problematic because multiple genes and environmental factors determine complex behavior, and the many different dependence phenotypes may have different genetic underpinnings

But, whereas the acute effects of nicotine in the VTA predominantly affect GABA neurons, the nAChRs in these cells desensitize rapidly, leading to a long-lasting excitation of the DA neurons through removal of their inhibition

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The generative performance of the model was then assessed by simulating sequences of choices ( n = 2000 model choices) for n = 55 mice with their respective model parameters (Fig