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Mind if I smoke? is an old refrain from the days when smoking was a ubiquitous habit and people frequently puffed on cigarettes in offices, on airplanes and at restaurants

Additionally, factors like hydration levels, physical activity, and the functioning of the liver and kidneys play a significant role in how quickly nicotine is processed and eliminated from the body

Thus, some investigators argue that because of known nicotinic receptor interactions with angiotensinconverting enzyme 2 (ACE2), a channel for SARSCoV2 entry into cells, nicotine exposure can increase the risk for COVID19 damage, including neuroinfection [34]

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