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[50] The long-term toxicity is subject to the additives and contaminants in the e-liquid

While that is gobbledygook to the average person, it basically means that the app converts cigarette smoke inhaled to particulate matter (PM) in wildfire smoke that has a diameter of less than 2.5 micrometers, which has an increased chance of being breathed into human lungs

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Hughes JR, Keely JP, Niaura RS, Ossip-Klein DJ, Richmond RL, Swan GE

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Lung cancer death rates by smoking status: comparison of the Three-Prefecture Cohort study in Japan to the Cancer Prevention Study II in the USA