can cigarettes make you infertile The Damaging Effects of Smoking on Fertility Smoke Without Fire: The Effects
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Lowering the effectiveness of cancer treatment

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[31] After cigarette butts are discarded, they can leach toxins including nicotine, arsenic, polycyclic aromatic hydrocarbons and heavy metals into the environment

However, as you build up more of a tolerance to nicotine over time, you will often require a higher dose to enjoy the same effects
"Smoking in Restaurants: Rejoinder to Alamar and Glantz" (PDF)