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Using an intracranial self-stimulation reward-based foraging task, we investigated in mice the impact of chronic nicotine on midbrain dopamine neuron activity and its consequence on the trade-off between exploitation and exploration

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In summary, we identified distinct neural bases for the initiation and sustenance of substance use, represented by reduced GMV in the left and right vmPFC, respectively

What would happen to Nicorette gum or NicoDerm patch sales if the CDC started alerting smokers to the truth, that more ex-smokers quit cold turkey each year than by all other methods combined, that approved quitting products were benefitting only a tiny fraction of all successful ex-smokers, about 8 percent

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