what chemicals are in smokeless tobacco Some common forms of oral and its constituents Smokeless Tobacco Booklet | Health
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Cigarettes were reformulated, not so much to reduce tar but to fool the machines, according to an NCI report

These products are also tested above industry standards and are free of heavy metals, pesticides, and microbials found in other blunt wrap alternatives
Nicotine is the addictive substance found in tobacco, and it is delivered into the bloodstream when the smoker inhales

The trial did not find a significant increase in the rates of neuropsychiatric adverse effects that interfered with usual daily functioning with use of either varenicline or bupropion relative

Richter JE, Vaezi MF

The safest options share a few important characteristics