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A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

Hydration and gradual dose escalation may minimize this concern

The increase in AMP concentrations relieves the inhibition of PFK-1 by ATP, activating glycolysis

Secondly, the intrinsic immunogenicity of monoclonal antibodies may trigger anti-drug antibody (ADA) responses, which could potentially undermine therapeutic efficacy and lead to adverse reactions

We further investigated whether the attenuated transactivation activity (Fig

Clinical trials demonstrated its IOP lower effect within 2 hours of administration and additive effects when combined with other medication such as latanoprost