glp 1 pharmacology GLP-1 Discovery of GLP-1–Based Drugs for
Description
This reflects the pattern: U.S

writingreview and editing, F.R.P., M.B., S.M

CURRENTLY AVAILABLE GLP-1RA BASED THERAPIES FOR OBESITY In 1964, it was discovered that when glucose was administered orally, more insulin was secreted than when it was injected intravenously, confirming the existence of incretin, a gastrointestinal factor that promotes insulin secretion [21]

Methodology We conducted a search for English-language original studies and meta-analyses published between 2010 and 2024 using PubMed, Medscape, and MEDLINE

Tirzepatide is given as an injection
Patent terms, supplementary protection certificates (the European equivalent of patent term extensions), regulatory exclusivity periods, and the timing of initial product approvals all vary by country
