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Variants class: variants were classed into class 3 (VUS), class 4 (LP, likely pathogenic) and class 5 (P, pathogenic) according to the ACMG criteria for variant classification [21]

Iqos has mainly been promoted in countries that have introduced smoking or tobacco advertising bans and where cigarette sales were falling, according to Baths analysis

Industry figures have called for a national crackdown on the problem, including for federal and state police to use their powers to investigate and dismantle illicit tobacco gangs and enforce hefty fines for businesses caught selling illicit products