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3 Materials and Methods 3.1 Data Sources We used Chinas IO tables for 2007, 2012, and 2017 compiled every 5 years by the NBSC (Ministry of Natural Resources), issued by the Ministry of Natural Resources ( The entire mining sector was not available in Chinas IO tables

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Through Y maze, new object recognition and radial arm maze assessment, nicotine metabolites cotinine and 6-hydroxy-L-nicotine, also showed cognitive improvement effects, positively regulating the expression of brain-derived neurotrophic factor (BDNF), neuronal specificity and postsynaptic memory consolidation related protein (arc) and proinflammatory factor interleukin one beta (IL-1) in Alzheimers rats induced by A, exhibiting higher affinity with 42 nAChR and 7 compared to nicotine

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(2) We have already found that Nrf2 is the key mediator in the protective effect of AZI on airway epithelial barrier, but how AZI activates Nrf2 is still unknown, which is our next research objective

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