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How Smoking Affects Testosterone Production The exact mechanisms by which smoking affects testosterone production are not fully understood

Only an early Dutch study from 1990 involving female RA patients (control patients with soft-tissue rheumatism and osteoarthritis) reported that smoking had a protective effect in RA, albeit they only investigated recent smoking and their controls were not from the general population [4]
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Most cigarette butt density data were available in graphical formats, which were extracted using WebPlotDigitizer approximations

Klaver JH, Greve EL, Goslinga H, Geijssen HC, Heuvelmans JH

& Afifi, R
