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A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas

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Mutp53 types in cancer TP53 is located on the short arm of human chromosome 17 (17p13.1) and consists of 11 exons, 10 introns and 393 amino acid residues

Mutant p53 suppresses innate immune signaling to promote tumorigenesis

Ongoing studies in our group, utilizing non-invasive imaging of the tumor reductive state, circulating biomarkers of Nrf2 hyperactivation and spatial transcriptomic analysis of primary and recurrent HNSCC tumors are attempting to define the clinical window in which activation of this pathway is expected to generate a maximal deleterious effect on both conventional and ICI-based treatment efficacy

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