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Nature 515, 182184
2008, Noyan-Ashraf et al
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Obesity has an even greater impact on SM function and composition

WCDD301 shows a strong affinity ( K i 0.13 M) for the EphA4 receptor, comparable with other reported EphA4 agonists (40)

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When participants who had been taking semaglutide were randomized to either continue the medication or switch to placebo after 20 weeks, those who continued treatment maintained their weight loss, while those switched to placebo regained significant weight
