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Although interactions between pharmacokinetic drugs and tobacco smoke are primarily attributed to PAHs rather than nicotine, the latter is significantly involved in pharmacodynamic interactions through the activation of the sympathetic nervous system (Benowitz, 1997)

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In practice, this results in policies that apply similar restrictions across dissimilar products, limiting the ability of the regulatory framework to incentivize transitions away from the highest-risk forms of nicotine use

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Surgeon General's Warning: Cigarette Smoke Contains Carbon Monoxide

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