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[118] At sufficiently high doses, it is associated with nicotine poisoning, [22] which, while common in children (in whom poisonous and lethal levels occur at lower doses per kilogram of body weight [72] ) rarely results in significant morbidity or death

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First, I fully accept that its not always easy to say exactly where the line falls when it comes to an acceptable proportion of goods to harmsbut thats actually not a huge problem, because its rarely necessary to know precisely where the line is

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