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As of early 2026, only 13 state Medicaid programs cover GLP-1 medications for weight loss, down from 17 states at the start of the year California, New Hampshire, Pennsylvania, and South Carolina dropped coverage on January 1, 2026, citing budgetary constraints from the high cost of medications like Ozempic, Wegovy, and Zepbound

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17 Conversely, findings from another population-based study suggested there was no overall increased risk of DR associated with GLP-1RA use, while a meta-analysis indicated albiglutide, a GLP-1RA no longer commercially available due to limited prescribing, was associated with an increased risk of early worsening (the four GLP-1RAs available did not exhibit a statistically significant association with DR)

In the context of breast reconstruction, GLP-1 RAs may help broaden eligibility for autologous procedures such as DIEP flap reconstruction

Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis