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An additional study has explored which component of e-cigarette liquid (independent of nicotine and/or flavorings) may be contributing to these adverse vascular outcomes [112]
Nicotine Tob Res [DOI] [PMC free article] [PubMed] [Google Scholar] 92.Spindle TR, Hiler MM, Cooke ME, Eissenberg T, Kendler KS, Dick DM

Smoking both tobacco and marijuana synergistically increased the risk of respiratory symptoms and COPD

M., De Falco, E., Chimenti, I., Cammisotto, V., Valenti, V., Coluzzi, F., Cavarretta, E., Carrizzo, A., Prati, F., Carnevale, R., & Frati, G

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This is because of its high bioavailability rate