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At best, you only absorb about 50% of the nicotine, which equates to 2 or 3 mg

This leads to dependence

"Although the acute effects are certainly intriguing in these rodents, I would not generalize to humans given the data on cannabis use and arterial, cardiac or pulmonary problems," said Mitch Earleywine, a member of NORML's advisory board and a professor of psychology at the State University of New York at Albany

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Toxicokinetics and toxicodynamics of ayahuasca alkaloids N, N-dimethyltryptamine (DMT), harmine, harmaline and tetrahydroharmine: clinical and forensic impact