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While the extensive HPHC list of 2012 includes 93 chemicals, which are categorized as carcinogenic, respiratory, cardiovascular, or reproductive toxicants or addictive compounds, it fails to include microorganisms (bacteria and fungi) that have been shown to contribute to adverse health outcomes among tobacco users

Further, it is difficult to ascertain whether local governments can or cannot enact stricter ordinances

In 2009, the Food and Drug Administration gained the authority to regulate tobacco product manufacturing and marketing

Micromedex DrugReax System categorizes interactions into three degrees of severity, major, moderate, and minor, and the strength of the reporting into five categoriesexcellent, good, fair, poor, and unlikely (DRUG-REAX, 2024)

Essentially, the increasing awareness regarding the higher safety of e-cigarettes than traditional ones, particularly among the young population, contributes to the growth in sales