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In a randomized trial, 1,246 people who smoked at least five cigarettes daily and were motivated to quit underwent therapy that consisted of either e-cigarettes plus smoking-cessation counseling or counseling only

40 In addition, it was observed in a cohort of 16 healthy human volunteers that increased endothelial progenitor cells, as well as E-selectin positive microvesicles in circulation, were induced by only 10 puffs of E-cig vapor

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Cognitive Behavioral Therapy (CBT) 21 , Motivational Interviewing 22 , Contingency Management 23 , and Mindfulness-based interventions 24 have all shown efficacy, but often require trained personnel and structured setting resources that may be limited in low- and middle-income countries