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Since nicotine is rapidly eliminated from the brain, its effects on pain reduction become more complicated under chronic exposure conditions, where the impacts of nicotine withdrawal symptoms and nAChR desensitization outweigh the analgesic effects of absorbed nicotine, thereby resulting in elevated pain sensitivity [9] (Fig

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Oxid Med Cell Longev 2019:7092151 Su Y et al (1998) Effect of cigarette smoke extract on nitric oxide synthase in pulmonary artery endothelial cells